Role of TLR4 in LPS-induced mechanical inflammatory hyperalgesia in the mice paw.

<p>(<b>A</b>) HePas mice received intraplantar (i.pl.) injection of LPS (30–300 ng/paw) or saline (20 µl). (<b>B</b>) HePas and Hej mice received i.pl. injection of LPS (100 ng/paw). Mechanical hyperalgesia was evaluated 1–24 h after LPS injection. *<i>P</i><0.05 compared with saline control; #<i>P</i><0.05 compared with HePas injected with LPS (Panel C). One-way ANOVA followed by Tukey's t test.