Immunoreactivity for acetylated histone H4 in nuclei of airway epithelial cells.

<p>(A) Photomicrograph of immunopositive nuclei (brown) in epithelial cells lining the trachea, original magnification ×400. (B) Percent positive cells in the trachea in the model of an allergen-induced acute exacerbation of chronic asthma. OVA-exposed animals treated with vehicle alone are compared to unexposed animals or to animals treated with ISU201 or dexamethasone. Data are mean ± SEM (<i>n</i> = 6 samples per group). Significant differences relative to the naïve group are shown as **(p<0.01); relative to the vehicle-treated group are shown as #(p<0.05).