Concentrations of the nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) in mouse lung homogenates of untreated (naïve) control as well as <i>Pseudomonas</i> infected mice treated with PBS or the arginase inhibitor 2(S)-amino-6-boronohexanoic acid (ABH).

<p>ADMA was significantly lower in naïve compared to <i>Pseudomonas</i> infected lungs (*: p = 0.0001, Kruskal-Wallis test). The L-arginine/ADMA ratio, which can be used as an index of NOS impairment, was significantly reduced in infected lungs (*: p<0.0001, ANOVA). Treatment with ABH did not change ADMA concentrations but resulted in normalization of the L-arginine/ADMA ratio. (p<0.001, t-test).