<p>(a) A two-color flow cytometric method was used to isolate leukocyte populations of the lymphocyte (B and T-cells) and myeloid lineages, with the unstained control displayed in the left panel. (b–d) At two days a T-lymphopenia was present. At one week of HFD B-cell populations were diminished in the HF group, while T-cell populations were not significantly affected. After six weeks bone marrow lymphocyte populations were depressed and the myeloid lineage proliferated in response to HFD. The suppression of lymphocytes accompanied by myeloid expansion is a classic phenotype of hematopoietic aging. These changes may lead to defects in adaptive immunity. Each time point was drawn from distinct cohorts of animals, as such, comparisons can onl...
Bone marrow stromal cells (BMSC) play essential roles in hemopoiesis. In the present study, bone mar...
Although hematopoietic stem cells (HSCs) have traditionally been thought to possess the ability to g...
Production of T lymphocytes by the thymus declines with age, and is associated with declining immune...
<p>(a) Total BM cells harvested for flow cytometry were not different between HF and RD animals at a...
<p>(a) A representative gating scheme to isolate KLS and SP-KLS cells is shown. HSCs (SP-KLS) were a...
The bone marrow (BM) niche is the primary site of hematopoiesis, and cues from this microenvironment...
Background: Obesity has been associated with chronic inflammation and oxidative stress. Both conditi...
Lymphocyte development declines with age, which in turn contributes to the reduced replenishment of ...
The bone marrow (BM) niche is the primary site of hematopoiesis, and cues from this microenvironment...
Current models propose that reductions in the number of lymphoid-biased hematopoietic stem cells (Ly...
Aging of the hematopoietic stem cell compartment is believed to contribute to the onset of a variety...
Using two-color immunofluorescence, multiparameter flow cytometry has been used to examine the antig...
Bone marrow (BM) stem cells (BMSCs) are an important source for cell therapy. The outcome of cell th...
Summary: Current models propose that reductions in the number of lymphoid-biased hematopoietic stem ...
B lymphopoiesis declines with age in humans, mice, and rabbits. Impaired B lymphopoiesis correlates ...
Bone marrow stromal cells (BMSC) play essential roles in hemopoiesis. In the present study, bone mar...
Although hematopoietic stem cells (HSCs) have traditionally been thought to possess the ability to g...
Production of T lymphocytes by the thymus declines with age, and is associated with declining immune...
<p>(a) Total BM cells harvested for flow cytometry were not different between HF and RD animals at a...
<p>(a) A representative gating scheme to isolate KLS and SP-KLS cells is shown. HSCs (SP-KLS) were a...
The bone marrow (BM) niche is the primary site of hematopoiesis, and cues from this microenvironment...
Background: Obesity has been associated with chronic inflammation and oxidative stress. Both conditi...
Lymphocyte development declines with age, which in turn contributes to the reduced replenishment of ...
The bone marrow (BM) niche is the primary site of hematopoiesis, and cues from this microenvironment...
Current models propose that reductions in the number of lymphoid-biased hematopoietic stem cells (Ly...
Aging of the hematopoietic stem cell compartment is believed to contribute to the onset of a variety...
Using two-color immunofluorescence, multiparameter flow cytometry has been used to examine the antig...
Bone marrow (BM) stem cells (BMSCs) are an important source for cell therapy. The outcome of cell th...
Summary: Current models propose that reductions in the number of lymphoid-biased hematopoietic stem ...
B lymphopoiesis declines with age in humans, mice, and rabbits. Impaired B lymphopoiesis correlates ...
Bone marrow stromal cells (BMSC) play essential roles in hemopoiesis. In the present study, bone mar...
Although hematopoietic stem cells (HSCs) have traditionally been thought to possess the ability to g...
Production of T lymphocytes by the thymus declines with age, and is associated with declining immune...