CXCL12 expression in normal pancreas is decreased in dysplastic epithelium.

<p>Representative 200× images of the same (A) normal or (B) pancreatic ductal adenocarcinoma (PDAC) tissues shown at 1000× magnification in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0090400#pone-0090400-g001" target="_blank">Figure 1</a>. Representative serial section images of a pancreatic intestinal neoplasm (PanIN) lesion at (C) 200× or (D) 1000× magnification. Serial tissue sections were immunostained with antibodies to CK19, CXCL12, CXCR4, and CXCR7, or the isotype controls. n = 25 different normal tissues from 21 individual patients, 82 different tissues from 29 different PDAC patients, or 19 pathologically confirmed PanIN lesions.