<p>Single sgRNA/Gene: A mixture of 4 sgRNAs, each targeting a single site in each of the 4 genes. Dual sgRNAs/Gene: Another distinct sgRNA of each gene, together with the tested 4 sgRNAs targeting double site in each of the 4 genes.</p
The rat is a powerful model for the study of human physiology and diseases, and is preferred by phys...
Genes that were independently mutated in at least two different populations by Founder gene deletion...
*<p>If the number of exons is greater than 1, the number of exons in which the coding sequence is co...
<p>(a) PCR identification of sgRNA:Cas9-mediated site-specific cleavage of the endogenous <i>ApoE</i...
<p>(a) Detection of Cas9:sgRNA-mediated off-target cleavage <i>of Prkdc</i> OTS-4 in all founders (#...
<p>(a) Detection of Cas9:sgRNA-mediated site-specific cleavage of the endogenous <i>ApoE</i>, <i>B2m...
<div><p>The CRISPR/Cas9 system has been proven to be an efficient gene-editing tool for genome modif...
The laboratory rat is one of the most studied model organisms for human heath and disease. Researche...
The CRISPR/Cas9 system has been proven to be an efficient gene-editing tool for genome modification ...
More than a thousand quantitative trait loci (QTLs) relevant to many aspects of complex human diseas...
Identification of more than 12,000 single nucleotides that vary among genes from different rat strai...
<p>A summary of the 15 HKG (housekeeping genes) considered as reference gene candidates in SD rats.<...
a. Original sgRNA proposed by Mali et al., 2013 [3]. Extension-Flip (EF) sgRNA proposed by Chen et a...
SummarySevere combined immunodeficiency (SCID) mice, the most widely used animal model of DNA-PKcs (...
(A) Schematic representation of the sgRNA sequence targeted in Exon I of Sfabd-A locus. (B) Differen...
The rat is a powerful model for the study of human physiology and diseases, and is preferred by phys...
Genes that were independently mutated in at least two different populations by Founder gene deletion...
*<p>If the number of exons is greater than 1, the number of exons in which the coding sequence is co...
<p>(a) PCR identification of sgRNA:Cas9-mediated site-specific cleavage of the endogenous <i>ApoE</i...
<p>(a) Detection of Cas9:sgRNA-mediated off-target cleavage <i>of Prkdc</i> OTS-4 in all founders (#...
<p>(a) Detection of Cas9:sgRNA-mediated site-specific cleavage of the endogenous <i>ApoE</i>, <i>B2m...
<div><p>The CRISPR/Cas9 system has been proven to be an efficient gene-editing tool for genome modif...
The laboratory rat is one of the most studied model organisms for human heath and disease. Researche...
The CRISPR/Cas9 system has been proven to be an efficient gene-editing tool for genome modification ...
More than a thousand quantitative trait loci (QTLs) relevant to many aspects of complex human diseas...
Identification of more than 12,000 single nucleotides that vary among genes from different rat strai...
<p>A summary of the 15 HKG (housekeeping genes) considered as reference gene candidates in SD rats.<...
a. Original sgRNA proposed by Mali et al., 2013 [3]. Extension-Flip (EF) sgRNA proposed by Chen et a...
SummarySevere combined immunodeficiency (SCID) mice, the most widely used animal model of DNA-PKcs (...
(A) Schematic representation of the sgRNA sequence targeted in Exon I of Sfabd-A locus. (B) Differen...
The rat is a powerful model for the study of human physiology and diseases, and is preferred by phys...
Genes that were independently mutated in at least two different populations by Founder gene deletion...
*<p>If the number of exons is greater than 1, the number of exons in which the coding sequence is co...
DOI
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