The <i>in vitro</i> antitumour activity testing results.

<p>The data were obtained by the MTT assay against human lung carcinoma A549, cervix epithelial carcinoma HeLa, malignant melanoma G-361, ovarian carcinoma A2780 and <i>cisplatin</i>-resistant ovarian carcinoma A2780R cell lines for <b>1</b>–<b>3</b> and <i>cisplatin</i>. The cells were exposed to the compounds for 24 h. Measurements were performed in triplicate and each cytotoxicity experiment was repeated three times. The given IC₅₀±S.D. (µM) values represent an arithmetic mean. The asterisk (*) denotes a significant difference (<i>p</i><0.05) between the studied complexes and <i>cisplatin</i> (A); the plot of resistance factors calculated as IC₅₀(A2780R)/IC₅₀(A2780) for <b>1</b>–<b>3</b> and <i>cisplatin</i> (B).