<p>Young and old Ad-MSCs were treated with 5 µM 5-Azacytidine for 48 h. mRNA levels of (A) <i>TET2</i>, (B) <i>TET3</i>, (E) Sox2, (F) <i>Lin28A</i> (2 donors from the young Ad-MSCs had to be excluded from the data set, due to artefacts in the melting curve), (G) <i>Oct4</i> and (H) <i>Nanog</i> were determined by qRT-PCR (N = 6, n = 3/age group). (I) Expression changes of <i>TET2, TET3, Lin28A</i>, <i>Oct4</i>, <i>Nanog</i> and <i>Sox2</i> were confirmed on the protein level by Western blot analysis (Representative figure for N = 2/group). <i>GAPDH</i> was used for normalization. Data are presented as relative expression changes (log<sub>10</sub>) of 5-Azacytidine treated Ad-MSCs compared to the corresponding untreated Ad-MSCs. Distributio...
<p>(A) 5-aza-dC treated NuLi-1 cells show reduced proliferation and apoptosis four days after treatm...
In order to study the effect of DNA methylation on gene expression, human cancer cell lines were tre...
The radioresistance of tumor cells remains a major cause of treatment failure in nasopharyngeal carc...
<p>Basal mRNA levels of (A) <i>TET2</i> and (B) <i>TET3</i> were determined by qRT-PCR in Ad-MSCs fr...
The therapeutic value of adipose-derived mesenchymal stem cells (Ad-MSCs) for bone regeneration is c...
The therapeutic value of adipose-derived mesenchymal stem cells (Ad-MSCs) for bone regeneration is c...
Epigenetic modifiers, like the DNA methylation inhibitor 5-Azacytidine (5-AzaC), have been shown to ...
<p>(A) M-/U-MSP analysis of <i>miR-124-1</i> promoter methylation status and stem-loop qRT-PCR analy...
Phenotype definition is controlled by epigenetic regulations that allow cells to acquire their diffe...
Demethylating agent, 5-Azacytidine (5-Aza), has been shown to be active in treatment of myeloid mali...
The hypomethylating agent 5-Azacytidine epigenetically modulates various genes, including tumor supp...
5-Azacytidine (5-azaC), a methyltransferase inhibitor and anticancer drug, can promote several cellu...
Human adipose tissue is a great source of adult mesenchymal stem cells (MSCs) which are recognized f...
Azacytidine (AzaC) and decitabine (AzadC) are cytosine analogs that covalently trap DNA methyltransf...
Background: Global deregulation of DNA methylation is one of the crucial causes of hepato cellular c...
<p>(A) 5-aza-dC treated NuLi-1 cells show reduced proliferation and apoptosis four days after treatm...
In order to study the effect of DNA methylation on gene expression, human cancer cell lines were tre...
The radioresistance of tumor cells remains a major cause of treatment failure in nasopharyngeal carc...
<p>Basal mRNA levels of (A) <i>TET2</i> and (B) <i>TET3</i> were determined by qRT-PCR in Ad-MSCs fr...
The therapeutic value of adipose-derived mesenchymal stem cells (Ad-MSCs) for bone regeneration is c...
The therapeutic value of adipose-derived mesenchymal stem cells (Ad-MSCs) for bone regeneration is c...
Epigenetic modifiers, like the DNA methylation inhibitor 5-Azacytidine (5-AzaC), have been shown to ...
<p>(A) M-/U-MSP analysis of <i>miR-124-1</i> promoter methylation status and stem-loop qRT-PCR analy...
Phenotype definition is controlled by epigenetic regulations that allow cells to acquire their diffe...
Demethylating agent, 5-Azacytidine (5-Aza), has been shown to be active in treatment of myeloid mali...
The hypomethylating agent 5-Azacytidine epigenetically modulates various genes, including tumor supp...
5-Azacytidine (5-azaC), a methyltransferase inhibitor and anticancer drug, can promote several cellu...
Human adipose tissue is a great source of adult mesenchymal stem cells (MSCs) which are recognized f...
Azacytidine (AzaC) and decitabine (AzadC) are cytosine analogs that covalently trap DNA methyltransf...
Background: Global deregulation of DNA methylation is one of the crucial causes of hepato cellular c...
<p>(A) 5-aza-dC treated NuLi-1 cells show reduced proliferation and apoptosis four days after treatm...
In order to study the effect of DNA methylation on gene expression, human cancer cell lines were tre...
The radioresistance of tumor cells remains a major cause of treatment failure in nasopharyngeal carc...