Development of the Direct Suzuki–Miyaura Cross-Coupling of Primary <i>B</i>‑Alkyl MIDA-boronates and Aryl Bromides

The development of a palladium-catalyzed sp³–sp² Suzuki–Miyaura cross-coupling of <i>B-</i>alkyl-<i>N</i>-methyliminodiacetyl (<i>B</i>-alkyl MIDA) boronates and (hetero)­aryl bromides is reported. This transformation is tolerant of a variety of functional groups (F, NO₂, CN, Cl, COCH₃, and CHO). <i>B</i>-Alkyl MIDA boronates allow an efficient cross-coupling reaction directed toward the synthesis of unsymmetrical methylene diaryls as well as alkylated arenes in good to excellent yields