Forced swim test in rats for evaluating antidepressant-like activity of LPM570065 and desvenlafaxine.

<p>The effects of LPM570065 (black column), desvenlafaxine (red column) and vehicle (blue column) on the immobility time in the forced swim test over a 4-h post-dosing period are indicated as follows: (A) for acute administration and (B) for chronic administration. Acute (0.06 mmol·kg⁻¹) and chronic (0.06 mmol·kg⁻¹·day⁻¹ for 14 days) administration were performed by providing rats the oral suspensions of LPM570065 and desvenlafaxine. At 0.5, 1, 2 and 4 h post-dosing, rats were placed in the cylinder again for 5 min (test session), and the total duration of immobilization was recorded. Data are presented as the mean±SD (n = 10) in the form of a histogram; ***<i>p</i><0.001, **<i>p</i><0.01, *<i>p</i><0.05 drug vs. relative vehicle; one-way ANOVA, Bonferroni’s post-test.