The effects of LPM570065, desvenlafaxine and vehicle on the extracellular monoamine levels after chronic administration.

<p>The effects of LPM570065 (black line), desvenlafaxine (red line) and vehicle (blue line) on the extracellular 5-HT, DA and NE levels in the rat striatum after chronic administration (oral suspension: 0.06 mmol·kg⁻¹·day⁻¹ for 14 days) are indicated in (A), (B) and (C), respectively. LPM570065, desvenlafaxine or vehicle was administered at time 0 min. Data are presented as the mean±SD, n = 7–8; ***<i>p</i><0.001 LPM570065 vs. vehicle; <i>^###p</i><0.001 desvenlafaxine vs. vehicle; two-way ANOVA with repeated measures. (D) The overall effects on the extracellular 5-HT, DA and NE levels in the rat striatum following the chronic treatment with LPM570065 (black column), desvenlafaxine (red column) or vehicle (blue column). The columns represent the AUC_{0-t min} values calculated as the differences in relative changes in the extracellular monoamine levels over a period between the drug-treated and vehicle-treated groups (t = 240 min for 5-HT and NE; t = 160 min for DA). Data are presented as the mean±SD, n = 7–8; ***<i>p</i><0.001 drug vs. vehicle; one-way ANOVA.