Decreased postprandial TG secretion, intestinal TG hydrolase activity, and intestinal fatty acid oxidation in intestine-specific CGI-58 knockout mice.

<p>A: Postprandial TG secretion. Male mice (n = 6) were pre-treated with the lipoprotein lipase inhibitor Tyloxapol (500 mg/kg) for 30 min and then administered by gavage of 0.5 ml of olive oil. Blood samples were collected at indicated times post oil administration, and analyzed for plasma TG concentrations. Measurements of TG hydrolase activity (B) (n = 6), rates of fatty acid oxidation (C) (n = 6), intestinal cholesterol absorption (D) (n = 8), and fecal total neutral sterol excretion (E) (n = 8) in male CGI-58^f/f and CGI-58^f/f/cre mice were performed as described under <i>Experimental Procedures</i>. *<i>P</i><0.05 versus Control mice.