Effect of IGF-1 on ischemia-reperfusion induced blood brain barrier permeability.

<p>(A). Evans blue dye extravasation: IGF-1 treatment significantly reduced ischemia-induced increase in blood brain barrier permeability at 4h as indicated by decreased Evan’s blue dye in both cortex and striatum. Concentration of Evan’s blue is expressed as ratio of dye accumulation in the ischemic hemisphere to the non-ischemic hemisphere. Bars represent mean ± SEM. n = 6–8 in each group. *: p <0.05. (B) IgG expression: Western blot analysis of light and heavy chain IgG expression indicated that IGF-1 treatment reduced IgG-heavy chain expression at both 4h and 24h post stroke.