SecinH3 reduced the growth of colorectal HT29 tumor xenografts.

<p>The diameter of xenograft tumor established in mice was measured by ultrasound every 2 days during treatment (diagram a). T₁ was the control group. T₂ was the SecinH3 group. The tumors of the SecinH3 group were inhibited growth obviously, after daily intraperitoneal injections of SecinH3 for more than a week. There was significant difference between the two groups in the 11^th, 14^th days after treatment. Diagram (b) and(c) represent immunohistochemical straining results for Ki-67 of tumor from mice after treated with (b) or without SecinH3(c) for 14 days, (original magnification ×200). It seams that SecinH3 decreases the expression of Ki-67 in HT29 xenografts. Diagram (d) depicts the positive expression rate of Ki-67 in the tumors of mice bearing HT29 xenografts in the 14^th day after treatment with or without SecinH3. Diagram (e) depicts the positive expression of ARNO, pEGFR in the tumors of mice bearing HT29 xenografts after treatment with or without SecinH3 for 2 weeks. The ARNO and pEGFR expression of the two groups have significant difference. The diagrams show relative phosphorylation levels after normalization for GAPDH. Data are represented as the mean ± SEM. *<i>p</i><0.05, * *<i>p</i><0.01, n = 7.