SecinH3 reduced the proliferation and migration of HT29 and HCT116.

<p>Left column of diagram (a) are representative images of Tran swell assay of HT29 and HCT116 cells treated with SecinH3 in 0, 10, 20, and 40 µM respectively. The left pictures are the result of HT29 cells without SecinH3 (DMSO 0.2% for 48h) and with SecinH3 (20 µM for 48 h) (original magnification ×100). It seems that SecinH3 can inhibit the migration of HT29 and HCT116 cells. The results are correlation with the concentration of SecinH3 and the time. The diagrams (b) show relative cell number of HT29 and HCT116 determined by MTT assay in the presence of SecinH3 in 0, 10, 20, and 40 µM for 24, 48, and 72 h. It seems that SecinH3 can inhibit the infiltration of HT29 and HCT116 cells. The results are also correlation with the concentration of SecinH3 and the time. Data is represented as the mean ± SEM. * p<0.05, **p<0.01 (<i>n</i> = 5).