Modulation of cell cycle progression by Mitocur-1.

<p>MCF-7 cells were treated with Mitocur-1 (5 and 10 µM) for a period of 24 h. (<b>A</b>) shows the flow cytometry profiles of (PI)- stained cells of control, and Mitocur-1 (5 and 10 µM) treatment as described in Methods. (<b>B</b>) Quantitative cell cycle (DNA content) distribution (% of total) in the control and treatment groups. (<b>C</b>) MCF-7 cells were treated with Mitocur-1 (5 and 10 µM) for 24 h and subjected to Western blot analysis. Representative immunoblot images of cyclin A, cyclin B1 and cyclin D1 are shown. Values are expressed Mean ± SD; (n = 4). **, significantly different from control (P<0.01).