CCNA2 expression is associated with poor survival and tamoxifen resistance in ER+ breast cancer patients.

<p>Kaplan-Meier plot for DMFS of ER+ (<i>A</i>), ER- (<i>B</i>) or tamoxifen treated (<i>C</i>) breast cancer patients grouped by the tertile of CCNA2 expression levels, significance was assessed by logrank test. (<i>D</i>) Log2 transformed mRNA expression values of CCNA2 in MCF-7 tumor xenografts treated with either tamoxifen or control. P values were calculated by unpaired two-tailed t test. Error bars represent mean ± SEM. (<i>E</i>) mRNA expression values of CCNA2 in tamoxifen resistant/sensitive MCF-7 subclones treated with tamoxifen or control. P values were calculated by unpaired two-tailed t test. Error bars represent mean ± SEM. (<i>F</i>) Gene set enrichment analysis of CCNA2 mRNA expression in relation to tamoxifen resistance gene set using breast cancer expression profiles (N = 2795).