Caspase-1/11-deficient macrophages show activation of classical apoptotic pathways in response to <i>Burkholderia</i> infection.

<p>Processing of caspases-1, -9, -7, -8, -3, and PARP and phosphorylation of JNK and p38 MAPK was detected by immunoblot in cell lysates of caspase-1/11-deficient and wild-type BMM infected with <i>B. pseudomallei</i> E8 and <i>B. thailandensis</i> E264 at MOI of 50∶1 at one, three, and twelve hours after infection. One experiment of at least three performed is shown. non-infected (n.i.).