Durability of humoral immune responses upon DNA vaccination up to 40 months post the last vaccination.

<p>(<b>A</b>) Two groups of vaccinated macaques were monitored for the maintenance of bAb responses to SIVmac239 for several years after the last vaccination. Macaques P082 and P090 are from the DNA&Protein group (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0091550#pone-0091550-g003" target="_blank">Figure 3</a>). The group of 8 DNA-only vaccinated macaques <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0091550#pone.0091550-Jalah1" target="_blank">[20]</a> received the same vaccine described in the DNA-only group described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0091550#pone-0091550-g003" target="_blank">Figure 3</a> but without IL-12 DNA as adjuvant. (<b>B</b>) Endpoint SIVmac239 Env bAb titers (in log) were measured from macaques P082 and P090 over 40 months after V4 and from the DNA-only group over 19 months after V4.