Parameter estimation in the Core network.

<p>A) Solved Pareto front for the Core network, showing the 3-D front (left) and projections (right 3 plots). Plotted in log space to accentuate small errors, showing: Pareto front (blue line), local solutions (red ), Pareto optimal solutions (), Anchor points (), and Utopian point (). Projection views are bounded by the relevant Anchor points, so many solved points may not be visible and scales vary (e.g. Wild Type and Behavioral values are very similar and produce a negligible front with no Pareto points other than the Anchors, 3rd from left). B) Sample of model outputs and optimally scaled surrogate data for the Pareto point closest to the Utopian, indicated by black arrows in A. Plot titles indicate measurement: experiment; relative error (). Notation as in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003498#pcbi-1003498-g002" target="_blank">Figure 2A</a>.