RAN, XPO7 and TPX2 expressions are associated with poor survival in high-grade serous epithelial ovarian cancer.

<p>Expression of RAN network proteins was evaluated as prognostic indicators in only the high-grade serous carcinomas by Kaplan–Meier analysis. Survival was defined as the time from surgery to death from ovarian cancer or last follow-up. The log-rank test was used to define statistical difference between groups. For panels A–H, low staining (blue line) defined by values <1, medium staining (green line) defined by = 1<2 and high staining (pink line) defined as ≥2. For panel I, samples are scored as negative (black line) or positive (grey line) for TPX2 staining. In A–I, p denotes significance among all groups. For panels J–K, negative TPX2 staining with low staining intensity of RAN (J –black line) or XPO7 (K – black line); negative TPX2 staining with medium+high staining of RAN (J – cyan line) or XPO7 (K – violet line); positive TPX2 staining with medium+high staining of RAN (J – grey line) or XPO7 (K – grey line). In J–K, p (top right hand corner) is calculated for black versus cyan (RAN, panel J) or violet (XPO7, panel K). In J–K, p (bottom left hand corner) is calculated for grey versus cyan (RAN, panel J) or violet (XPO7, panel K). A–K, p<0.05 are indicated in bold letters.