<p>(A) The module consists of a single negatively autoregulated node, whereas the context comprises nodes repressed by the TF in the module. (B) The internal retroactivity of the module increases with the DNA copy number of . As a result, the module becomes slower as increases. (C) The percentage increase in the response time of the module decreases with , that is, internal retroactivity increases the robustness to interconnection. Simulation parameters: , and is changed such that at the steady state. The context contains nodes each with DNA concentration for (low load: ; medium load: ; high load: ). The response time is calculated as the time required to reach of the steady state value.</p
Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2016.Cata...
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Compute...
The phenomenon of retroactivity describes the impact that a downstream system has on an upstream one...
<p>Time response at a steady state fixed at . The red and blue plots denote the cases with and witho...
Information exchange is a critical process in all communication systems, including biological ones. ...
<div><p>Predicting the dynamic behavior of a large network from that of the composing modules is a c...
Abstract—As with several engineering systems, bio-molecular systems display impedance-like effects a...
Synthetic biology is a bottom-up engineering discipline: biological modules are systematically desig...
Just like in many engineering systems, impedance-like effects, called retroactivity, arise at the in...
© 1963-2012 IEEE. The ability of cells to sense and respond to their environment is encoded in biomo...
As with several engineering systems, bio-molecular systems display impedance-like effects at interco...
Just like in many engineering systems, impedance-like effects, called retroactivity, arise at the in...
This paper considers the problem of attenuating retroactivity, that is, the effect of loads in biolo...
Abstract—The input/output dynamic behavior of a biomolec-ular system is affected by interconnection ...
<p>(A) The module in isolation. (B) The module in isolation displays sustained oscillations. (C) The...
Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2016.Cata...
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Compute...
The phenomenon of retroactivity describes the impact that a downstream system has on an upstream one...
<p>Time response at a steady state fixed at . The red and blue plots denote the cases with and witho...
Information exchange is a critical process in all communication systems, including biological ones. ...
<div><p>Predicting the dynamic behavior of a large network from that of the composing modules is a c...
Abstract—As with several engineering systems, bio-molecular systems display impedance-like effects a...
Synthetic biology is a bottom-up engineering discipline: biological modules are systematically desig...
Just like in many engineering systems, impedance-like effects, called retroactivity, arise at the in...
© 1963-2012 IEEE. The ability of cells to sense and respond to their environment is encoded in biomo...
As with several engineering systems, bio-molecular systems display impedance-like effects at interco...
Just like in many engineering systems, impedance-like effects, called retroactivity, arise at the in...
This paper considers the problem of attenuating retroactivity, that is, the effect of loads in biolo...
Abstract—The input/output dynamic behavior of a biomolec-ular system is affected by interconnection ...
<p>(A) The module in isolation. (B) The module in isolation displays sustained oscillations. (C) The...
Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2016.Cata...
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Compute...
The phenomenon of retroactivity describes the impact that a downstream system has on an upstream one...