Abnormality of estrous cycle in PK2, PKR2 single and compound heterozygotic female mice.

<p>Three female mice in wild-type group, six female mice in each three mutant groups were studied. Panel A shows that three mutant groups exhibited irregular and longer estrous cycles compared to the wild-type control. PKR2 heterozygotes and the compound heterozygous female mice exhibited more pronounced abnormality. Panel B shows the quantification of estrous cycle lengths (Mean ± S.E.), * p<0.05 ** p<0.01. Panel C shows the percentage of days at each stage in 20 days of observance. D: diestrus, M: metestrus, E: estrus, P: proestrus.