Comparison of the P-gp asymmetric ATP-bound state to ADP-bound Sav1866.

<p>Front view of A) the ADP-bound XRD structure of Sav1866, the central conformation of B) Run 4, and C) the branched D series simulations obtained from cluster analysis. The N- and C-terminal halves of each transporter are in gold and silver, respectively. Mg²⁺ is shown as green spheres and ATP is in CPK coloring. The phosphate groups of the lipid headgroups are shown in licorice.