Intranasal pretreatment with LTS61K or LTS61K/<i>Dermatophagoides pteronyssinus</i> (Der p) alleviates Der p-induced allergic asthma in mice.

<p>Mice were intranasally treated once in 1 week. After 2 weeks, mice were sensitized to and boosted with Der p mixed with incomplete adjuvant. After a final airway challenge, mice were sacrificed 3 days later and assessed for airway resistance based on (<b>A</b>) Penh values, (<b>B</b>) total infiltrated cells, and (<b>C</b>) cytokines in bronchoalveolar lavage fluid (BALF). (<b>D</b>) Hematoxylin and eosin staining. Red arrows indicate inflammatory cell infiltrates in the parenchyma and damaged epithelial cells in the bronchi. Results represent the mean ± standard error of the mean for n = 6–12 mice per group. *p<0.05, **p<0.01. Data are shown for 3 representative experiments.