Endothelium-dependent relaxation by 2-MeS-ADP is decreased in aortas from Ang II-hypertensive rats compared to control.

<p>Relaxation induced by 2-MeS-ADP (100 μM) in PE-contracted (3 μM) aortas from vehicle-treated control (white bars, n = 5) and vehicle-treated Ang II-hypertensive rats (black bars, n = 6). Experiments were conducted in the presence (+) or absence (−) of MRS-2179 (0.1 μM), a P2Y₁ receptor antagonist, MRS-2395 (0.1 μM), a P2Y₁₂ receptor antagonist and MRS-2211 (1 μM), a P2Y₁₃ receptor antagonist. Experimental values of the relaxation induced by 2-MeS-ADP were calculated relative to the maximal changes from the contraction produced by PE in each tissue, which was taken as 100%. Results are presented as mean ± SEM in each experimental group. *P<0.05 vs. respective vehicle-treated control rats. † P<0.05 vs. vehicle-treated Ang II rats.