Compounds have an anti-proliferative effect in cell migration assay in HGF stimulated lung tumor spheroids.

<p>Day 4 lung spheroids generated from H292, H1650, H1975 and A549 were treated with Erlotinib, Cetuximab, Crizotinib and MetMab in a dilution series in the presence of 20/ml of HGF for 48 hours to stimulate cell migration. Cell proliferation was determined by CellTiter-Glo Assay (Promega). Cell proliferation (RLU) was normalized to untreated control. Data are means <u>+</u> SEM with two to five replicates and is representative of two independent experiments.