The effects of EGFR and cMET compounds on 2D monolayer and 3D spheroid proliferation.

<p>Day 3 lung spheroids or monolayer cultures generated from H292, H1650, H1975 and A549 were treated for 72/ml HGF. IgG₁ kappa and DMSO were used as vehicle controls. Cell proliferation was determined by CellTiter-Glo Assay (Promega). Cell proliferation (RLU) was normalized to untreated control. Data points represent means <u>+</u> SEM with five replicates and is representative of two independent experiments.