THAP11 overexpression leads to inhibition of hemin induced erythroid differentiation of K562 cells.

<p>(A) THAP11 lentivirus infected K562 cells (THAP11-LV) and control cells were treated with 40 µM hemin for the indicated lengths of time and the benzidine-positive cells were counted. The pictures of cells treated with hemin for 5 days were shown in (B). (C) HBA mRNA level and (D) GPA mRNA level were detected using real-time PCR analysis. Real-time PCR results were expressed as fold induction relative to control cells at day 0 and normalized to GAPDH mRNA.