Protein expression detected by IHC from invasive breast carcinoma cases.

<p>(<b>A</b>) IGF1R-alpha moderate to strong membraneous staining in carcinoma cells; (<b>B</b>) IGF1R-alpha cytoplasmic staining; (<b>C</b>) IGF1R-beta intense cytoplasmic and membraneous staining; (<b>D</b>) IGF1R-beta cytoplasmic expression in neoplastic population; (<b>E</b>) IGF2R, predominantly granular cytoplasmic staining; (<b>F</b>) IGF2R expression limited to non-neoplastic epithelial remnants; (<b>G</b>) IGFBP2 moderate to intense cytoplasmic staining in neoplastic cells; (<b>H</b>) IGFBP2 cytoplasmic and dot-like pattern of staining. Scale Bar: 10 µm.