Dental abnormalities observed in homozygous <i>Slc25a21^{tm1a(KOMP)Wtsi}</i> mice.

<p>Dysmorphology analysis revealed underdeveloped, white incisors (A–B) in <i>Slc25a21^{tm1a(KOMP)Wtsi}</i> homozygous mice as compared to wild-type (C). Wholemount (D–F) and subsequent histological sections (G) demonstrated bacterial <i>lacZ</i> activity in cavities within lower jaw molars of <i>Slc25a21^{tm1a(KOMP)Wtsi}</i> homozygous (D,G) mice compared to heterozygous (E) and wild-type (F) mice. Focal fracturing of the surface dentine is indicated with a black arrow and necrosis of the pulp indicated with a red arrow (G). Micro-CT imaging demonstrated that the root aspect of lower jaw incisors was severely under developed (white arrow) and lacked enamel coating in homozygous <i>Slc25a21^{tm1a(KOMP)Wtsi}</i> mice (H–I) compared to wild-type (J).