Structural comparisons of the ChxR solution state with various classes of full-length OmpR/PhoB subfamily structures.

<p><i>A,</i> Structural superposition, through the receiver domain, of a full-length ChxR monomer (cyan) with a representative “closed” subclass full-length structure, MtrA (gold; PDB ID: 2GWR) from <i>M. tuberculosis. B,</i> Structural superposition, through the receiver domain, of a full-length ChxR monomer (cyan) with a representative “open” subclass full-length structure, DrrD (green; PDB ID: 1KGS) from <i>T. maritima</i>. ChxR is oriented as in panel A. <i>C,</i> Structural superposition, through the receiver domain, of a full-length ChxR monomer (cyan) with a representative “free” subclass full-length structure, HP1043 (blue; PDB ID: 2HQR) from <i>H. pylori</i>. ChxR is rotated 90° from panels A and B. In panels A-C dashed lines represent the α4–β5–α5 dimerization interface, while recognition helices are colored magenta.