Determining the optimal kinome profile of an ABL inhibitor.

<p>A: Biochemical components of kinase inhibitors that contribute to the specific targeting of <i>ABL1</i> dependent cell growth. The circle labelled ABL1 refers to biochemical ABL1 inhibition. B: Inhibitors with equal ABL1 and ABL2 affinity in an independent dataset <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0092146#pone.0092146-Davis1" target="_blank">[12]</a> are better in targeting <i>ABL1</i>-dependent cell growth than inhibitors with ABL1 activity alone. Poor ABL2 affinity signifies binding K_d differences between 4 and 26-fold compared to ABL1. Equal affinity signifies binding K_d differences between 0.5 and 4-fold.