Loss of ATRX does not affect telomere maintenance in mouse ES cells.
- David Clynes (540254)
- Clare Jelinska (540255)
- Barbara Xella (540256)
- Helena Ayyub (59289)
- Stephen Taylor (81177)
- Matthew Mitson (540257)
- Csanád Z. Bachrati (28135)
- Douglas R. Higgs (59293)
- Richard J. Gibbons (540258)
Publication date
March 2014
DOIAbstract
<p>(A) Representative image of a telomere FISH performed on a metaphase spread. (B) Quantitation of telomere fluorescence intensity in Atrx<i><sup>flox</sup></i> and Atrx<i><sup>null</sup></i> mES cells from >7000 telomeres for each cell type. (C) Terminal restriction length analysis of two independent clones (1, IF12 and 2, IG11) after digestion with HinfI and RsaI. Digested DNA was probed with a radiolabelled telomeric repeat.</p
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