<p>(A–B) Spectra of mutations are plotted as the percentage of clones containing a mutation at a particular location (nt) in the 368 nt <i>prot-lacZ</i>α construct for (A) A3G NPM or (B) A3F NGM. (C–F) Histograms show the number of mutations per <i>prot</i> or <i>lacZα</i> region for (C–D) A3G NPM or (E–F) A3F NGM.</p
<p>Amino acids from the neutralization-sensitive clone (085) were systematically inserted into the n...
<p><b>a)</b> Diagram of the HIV-1 NL4-3-MSS-eGFP/DsRED2 construct showing an expansion of the region...
<p>Amino acids from the neutralization-sensitive clone (048) were systematically inserted into the n...
<p>The ratio of white colonies to total colonies is defined as the population mutation frequency. Th...
<p>We generated near-full length sequences (<i>gag</i> to 3′LTR) of a subset of hypermutated viruses...
The human immunodeficiency virus (HIV) has a genome that is rich in adenine, and its rapid evolution...
<p>Jurkat cells were infected with the HIV lentiviral vector containing the WT promoter, with a sing...
<p>The mean percent of mutated nucleotides or the mean percent of replaced amino acids was calculate...
<p>(A) and (B) represent the estimated contribution by A3G and A3F to the HIV-1 mutation rate, respe...
<p>G-to-A mutation rates were estimated for (A) HIV-1 NL4-3 WT versus ΔVif infected LPMCs at 4 dpi; ...
<p>Amino acids from the neutralization-sensitive clone (007) were systematically inserted into the n...
<p>The percent either of R (A or G) or Y (C or T) nucleotides occurring in either the −1 (5′) positi...
<p>Each <i>prot</i> clone was individually analyzed to determine the percentage of clones that resul...
<p>(A) Introduction of single and double mutations into the 3′PPT or cPPT region in an NL4-3 backbon...
<p>(A) Plot of the frequency with which the library mutations occur in 1000 natural HIV-1 subtype B ...
<p>Amino acids from the neutralization-sensitive clone (085) were systematically inserted into the n...
<p><b>a)</b> Diagram of the HIV-1 NL4-3-MSS-eGFP/DsRED2 construct showing an expansion of the region...
<p>Amino acids from the neutralization-sensitive clone (048) were systematically inserted into the n...
<p>The ratio of white colonies to total colonies is defined as the population mutation frequency. Th...
<p>We generated near-full length sequences (<i>gag</i> to 3′LTR) of a subset of hypermutated viruses...
The human immunodeficiency virus (HIV) has a genome that is rich in adenine, and its rapid evolution...
<p>Jurkat cells were infected with the HIV lentiviral vector containing the WT promoter, with a sing...
<p>The mean percent of mutated nucleotides or the mean percent of replaced amino acids was calculate...
<p>(A) and (B) represent the estimated contribution by A3G and A3F to the HIV-1 mutation rate, respe...
<p>G-to-A mutation rates were estimated for (A) HIV-1 NL4-3 WT versus ΔVif infected LPMCs at 4 dpi; ...
<p>Amino acids from the neutralization-sensitive clone (007) were systematically inserted into the n...
<p>The percent either of R (A or G) or Y (C or T) nucleotides occurring in either the −1 (5′) positi...
<p>Each <i>prot</i> clone was individually analyzed to determine the percentage of clones that resul...
<p>(A) Introduction of single and double mutations into the 3′PPT or cPPT region in an NL4-3 backbon...
<p>(A) Plot of the frequency with which the library mutations occur in 1000 natural HIV-1 subtype B ...
<p>Amino acids from the neutralization-sensitive clone (085) were systematically inserted into the n...
<p><b>a)</b> Diagram of the HIV-1 NL4-3-MSS-eGFP/DsRED2 construct showing an expansion of the region...
<p>Amino acids from the neutralization-sensitive clone (048) were systematically inserted into the n...