Synthesis of Taurine-Containing Peptides, Sulfonopeptides, and <i>N</i>- and <i>O</i>‑Conjugates

Taurine-containing water-soluble peptidomimetics were designed and synthesized. <i>N</i>-terminal taurine acylations allowed synthesis of a number of taurine-containing peptides. <i>N</i>-protection of taurine with Cbz and SO₂-activation with benzotriazole followed by coupling with various amino esters, dipeptides and nucleophiles provided taurine <i>N</i>- and <i>O</i>-conjugates and sulfonopeptides