HO-1 induction increases HO-1, AKT and GSK3β expression in diabetic hearts.

<p>A:CoPP treatment significantly increased HO-1 expression levels (Means ± SD, n = 5. ^$<i>p</i><0.005 vs. sham, *<i>p</i><0.01 vs. diabetes,). B: Western blot analysis of AKT and p-AKT and p-Akt/Akt ratio in the different groups. CoPP treatment increased p-Akt levels while SnPP decreased the expression of p-AKT compared to the CoPP treated diabetic mice. (Means±SD, n = 5. ^$<0.05 vs. sham,*<i>p</i><0.05 vs. diabetes, #<i>p</i><0.05 vs. diabetes+CoPP C: Western blot analysis of GSK-3β in mice subjected to LAD ligation. CoPP treatment led to an increase in GSK-3β levels; SnPP decreased GSK-3β expression compared to the CoPP treated diabetic mice (Means ± SD, n = 5. ^$<0.05 vs. sham, * <i>p</i><0.05 vs. diabetes, #<i>p</i><0.05 vs. diabetes+CoPP).