STI and KYL block the AβO effect in vitro, allowing for the induction of LTP of the hippocampal slices from wild-type mice.

<p>(A) Hippocampal slices were exposed to ACSF (red) or AβOs (1 μM, white); arrow indicates the time of TBS and the plot show the fEPSP slope at different times. (B) Hippocampal slices were exposed to AβOs and STI (5 μM, black) or KYL (30 μM, gray), arrow indicates the time of TBS and the plot show the fEPSP slope at different times. (C) Inhibitors of c-Abl and EphA4 does not alter amplitude of basal fEPSP. Hippocampal slices were exposed to ACSF (white), STI (5 μM, black) or KYL (30 μM, gray) in basal conditions without stimulation. (D) Histogram showing Plot of fEPSP electrical recordings.