Lysobisphosphatidic acid controls endosomal cholesterol levels
- Chevallier, J.
- Chamoun, Z.
- Jiang, G.
- Prestwich, G.
- Sakai, N.
- Matile, S.
- Parton, R. G.
- Gruenberg, J.
Publication date
October 2008
DOI Publisher
American Society for Biochemistry & Molecular Biology (ASBMB) ISSN
0021-9258 Citation count (estimate)
114Abstract
Most cell types acquire cholesterol by endocytosis of circulating low density lipoprotein, but little is known about the mechanisms of intra-endosomal cholesterol transport and about the primary cause of its aberrant accumulation in the cholesterol storage disorder Niemann-Pick type C (NPC)
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