Clinical significance of FRA1 and FRA1^EMT genes in CRC.

<p>(A) Kaplan-Meier plots of recurrence-free survival in stage B and C CRC patients according to expression of the FRA1 gene (<i>FOSL1</i>). (B) Unsupervised clustering of stage B and stage C CRCs based on FRA1^EMT genes encompassing concordant probesets exhibiting significant expression differences between the two main groups. Clustering divides cancers into groups with mesenchymal and epithelial profiles. Samples are arranged along the X-axis and genes along the Y-axis. Genes are grouped into those downregulated (blue) or upregulated (orange) upon FRA1 knockdown in BE cells relative to the mean- and sample-centered scaled expression. (C) Kaplan-Meier plots of recurrence-free survival in stage B and C CRC patients based on expression of both <i>FOSL1</i> (low vs high) and mesenchymal (Mes, dark green) or epithelial (Epi, light green) subsets of FRA1^EMT genes. The log-rank test was used for comparisons.