Effect of IL-6 on trans-epithelial electrical resistance (TER) in Caco-2 intestinal epithelial monolayers.

<p>(A) IL-6 caused a dose-dependent decrease in TER over 48-h experimental period (<i>n</i> = 4). *<i>p</i><0.001 vs. control. (B) IL-6 (10 ng/ml) caused a time-dependant decrease in Caco-2 TER (<i>n</i> = 4). (C) Membrane specificity of IL-6 effect on Caco-2 epithelial resistance. IL-6 (10 ng/ml) was added to either apical, basolateral, or combined apical and basolateral compartments (<i>n</i> = 4). _*, <i>p</i><0.05 vs. control; _**, <i>p</i><001 vs. IL-6 addition to apical compartment alone.