Combined anti-cancer effect of 2ME and CsA in pancreatic cancers in vivo.

<p><b>A.</b> The mice tumors' volume in different groups. After six weeks of treatment, 2ME and/or CsA therapy decreased the tumors' volume, which was significantly smaller than those in the PBS control group (P<0.05, respectively); and the combination therapy decreased the tumor volume to 22.22±4.38 mm³, which was significantly smaller than those in the PBS and single-agent therapies (P<0.001, respectively). <b>B.</b> IHC results in different groups. Additionally, the IHC results confirmed the effect of 2ME and/or CsA: 2ME and/or CsA therapy decreased the HIF-lα and/or CypA positive tumor cells compared to those in the PBS control group; and the combination therapy decreased the positive tumor cells compared to PBS or single-agent therapies.