<p>The protein expression, intracellular IPA-3 content and cell response to treatment were classified as low (+), medium (++) or high (+++) with regard to the range of the observed values from the whole set of cell lines. To assess IPA-3 intracellular concentration, the measured values for mean fluorescence intensity (shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0092560#pone-0092560-g003" target="_blank">Fig. 3A</a>) were corrected for differences in the cell volume estimated from the measured cell diameter.</p
<p>(i) 50μM 2XP, (ii) 50μM 3BS, (iii) 50μM betulinic acid, (iv) 1% DMSO and (v) medium alone. Arrows...
Abstract: Aims: The aim of this study was to evaluate the effectiveness of specific monoclonal IBMR3...
<p><b>A</b>: Cytotoxic dose response of BM blasts from five <i>Flt3</i><sup>+/+</sup><i>MLL-ENL</i> ...
<p>(A) Cells were seeded at 2×10<sup>5</sup> cells/ml and IPA-3 at different concentrations was adde...
<p>(A, B) Results from flow cytometry measurements. The relative amount of IPA-3 was obtained as the...
<p>Top: Cells were treated for 2 h with 20 μM IPA-3 prior to 1 h incubation on fibronectin-coated su...
<p>(<b>A</b>) Relative protein levels of PAK1 in various cell lines. The signal intensities of the b...
<p>A) Western blotting analysis of p-IκB in HL60 cells. Cells were treated with the vehicle or with ...
<p>(A) The effect of IPA-3 on the cell proliferation rates of MIHA (upper, left panel), HepG2 (upper...
<p>Tumour cells from six B-ALL cell lines (C1, SEM, B1, UOCB1, Nalm6, KOPN8), two T-ALL cell lines (...
<p>(A) An increase in LC3 puncta was detected, by immunofluorescence in T47D and MCF7 cells after tr...
<p>Human CEM, HSB2, SUP-T1 and Jurkat cells were treated for 48 hr with I3C (15.6 up to 500 µM) or D...
<p>(A) HEL cells (at 1×10<sup>5</sup> cells/ml) were pretreated for 30 min with 20 μM IPA-3 and the ...
<p>(A) Concentration-response relationship of Yan 7874. (B) The impact of the inhibition of caspases...
<p>A. RL and Toledo cells were treated for 24 hrs, incubated with TMRE, and analyzed for stain uptak...
<p>(i) 50μM 2XP, (ii) 50μM 3BS, (iii) 50μM betulinic acid, (iv) 1% DMSO and (v) medium alone. Arrows...
Abstract: Aims: The aim of this study was to evaluate the effectiveness of specific monoclonal IBMR3...
<p><b>A</b>: Cytotoxic dose response of BM blasts from five <i>Flt3</i><sup>+/+</sup><i>MLL-ENL</i> ...
<p>(A) Cells were seeded at 2×10<sup>5</sup> cells/ml and IPA-3 at different concentrations was adde...
<p>(A, B) Results from flow cytometry measurements. The relative amount of IPA-3 was obtained as the...
<p>Top: Cells were treated for 2 h with 20 μM IPA-3 prior to 1 h incubation on fibronectin-coated su...
<p>(<b>A</b>) Relative protein levels of PAK1 in various cell lines. The signal intensities of the b...
<p>A) Western blotting analysis of p-IκB in HL60 cells. Cells were treated with the vehicle or with ...
<p>(A) The effect of IPA-3 on the cell proliferation rates of MIHA (upper, left panel), HepG2 (upper...
<p>Tumour cells from six B-ALL cell lines (C1, SEM, B1, UOCB1, Nalm6, KOPN8), two T-ALL cell lines (...
<p>(A) An increase in LC3 puncta was detected, by immunofluorescence in T47D and MCF7 cells after tr...
<p>Human CEM, HSB2, SUP-T1 and Jurkat cells were treated for 48 hr with I3C (15.6 up to 500 µM) or D...
<p>(A) HEL cells (at 1×10<sup>5</sup> cells/ml) were pretreated for 30 min with 20 μM IPA-3 and the ...
<p>(A) Concentration-response relationship of Yan 7874. (B) The impact of the inhibition of caspases...
<p>A. RL and Toledo cells were treated for 24 hrs, incubated with TMRE, and analyzed for stain uptak...
<p>(i) 50μM 2XP, (ii) 50μM 3BS, (iii) 50μM betulinic acid, (iv) 1% DMSO and (v) medium alone. Arrows...
Abstract: Aims: The aim of this study was to evaluate the effectiveness of specific monoclonal IBMR3...
<p><b>A</b>: Cytotoxic dose response of BM blasts from five <i>Flt3</i><sup>+/+</sup><i>MLL-ENL</i> ...