Properdin deficiency promotes increased macrophages in atherosclerotic lesions after feeding on a low fat diet.

<p>Quantitative immunohistochemistry of (<b>A</b>) % smooth muscle cells in aortic root plaques of male and female LDLR^−/−P^KO versus LDLR^−/−P^WT mice. Random areas in 15–20 plaques from n = 4–5 mice/group were analysed under high magnification using NIS elements software. Data presented are mean and IQR (<b>B</b>) Macrophage (MAC 387) index (percentage of the total cells/high power field within plaques) from the relevant groups, n = 5 mice/group were examined, mean and IQR, p<0.05, intergenotype comparisons were by two way ANOVA with a Mann Whitney U post test. (<b>C</b>) M2 (CD206) macrophage index, n = 5 mice/group examined, mean +/− SEM, p<0.05 (2 way ANOVA and Mann Whitney U test).