MiR-497 promoted chemosensitivity of gemcitabine.

<p>(A) AsPC-1 cells were transfected for 24 hours, and then treated with 100nM gemcitabine for 48 hours. Upregulation of miR-497 by transfection of mimics re-sensitized cells to gemcitabine. Downregulation of miR-497 by transfection of inhibitor decreased the sensitivity of cells to gemcitabine. (<b>B</b>) BxPC-3 cells were transfected for 24 hours, and treated with serially diluted gemcitabine (1nM, 10nM, 30nM, 100nM). Cells transfected with miR-497 mimics were more sensitive to gemcitabine. (<b>C</b>) Cells transfected with miR-497 inhibitor were more resistant to gemcitabine. (* <i>P</i><<i>0.05</i>).