Relationship between ALK IHC and FISH in the unselected 368 lung adenocarcinomas analysis.

Accurate identification of ALK positive lung carcinoma patients: novel FDA-cleared automated fluorescence in situ hybridization scanning system and ultrasensitive immunohistochemistry.

Esther Conde
Ana Suárez-Gauthier
Amparo Benito
Pilar Garrido
Rosario García-Campelo
Michele Biscuola
Luis Paz-Ares
David Hardisson
Javier de Castro
M Carmen Camacho
Delvys Rodriguez-Abreu
Ihab Abdulkader
Josep Ramirez
Noemí Reguart
Marta Salido
Lara Pijuán
Edurne Arriola
Julián Sanz
Victoria Folgueras
Noemí Villanueva
Javier Gómez-Román
Manuel Hidalgo
Fernando López-Ríos

BACKGROUND: Based on the excellent results of the clinical trials with ALK-inhibitors, the importanc...

Immunohistochemical screening for anaplastic lymphoma kinase (ALK) rearrangement in advanced non-small cell lung cancer patients

Park, Heae Surng
Lee, June Koo
Kim, Dong-Wan
Kulig, Kimary
Kim, Tae Min
Lee, Se-Hoon
Jeon, Yoon Kyung
Chung, Doo Hyun
Heo, Dae Seog

August 2012

Fluorescence in situ hybridization (FISH) is currently used to detect non-small cell lung cancer (NS...

Frequency of ALK rearrangement by FISH testing and its correlation with ALK-IHC in adenocarcinoma of primary lung origin

Moattar, Samar
Anwar, Namrah
Moatter, Tariq
Pervez, Shahid

June 2018

Anaplastic lymphoma kinase (ALK) gene can be oncogenic either by forming fusion with other genes, am...

Discordance between FISH, IHC, and NGS Analysis of ALK Status in Advanced Non–Small Cell Lung Cancer (NSCLC): a Brief Report of 7 Cases

Scattone A.
Catino A.
Schirosi L.
Caldarola L.
Tommasi S.
Lacalamita R.
Montagna E. S.
Galetta D.
Serio G.
Zito F. A.
Mangia A.

January 2019

BACKGROUND: Anaplastic lymphoma kinase (ALK) rearrangement represents a landmark in the targeted the...

Correlation of IHC and FISH for ALK Gene Rearrangement in Non-small Cell Lung Carcinoma: IHC Score Algorithm for FISH

Yi, Eunhee S.
Boland, Jennifer M.
Maleszewski, Joseph J.
Roden, Anja C.
Oliveira, Andre M.
Aubry, Marie-Christine
Erickson-Johnson, Michele R.
Caron, Bolette L.
Li, Yan
Tang, Hui
Stoddard, Shawn
Wampfler, Jason
Kulig, Kimary
Yang, Ping

March 2011

Introduction:Accurate, cost-effective methods for testing anaplastic lymphoma kinase gene rearrangem...

Three discrepant cases which had ALK IHC3+ and FISH “negative” results.

Jianya Zhou (542533)
Jing Zhao (21160)
Ke Sun (542534)
Bo Wang (86769)
Lijun Wang (176511)
Xi Chen (35903)
Jing Zheng (65946)
Qihan You (525773)
Xiaoling Wang (6503)
Wei Ding (690)
Jianying Zhou (506073)

March 2014

ALK, anaplastic lymphoma kinase; IHC, immunohistochemistry; FISH, fluorescence in situ hybridizat...

Combined Use of ALK Immunohistochemistry and FISH for Optimal Detection of ALK-Rearranged Lung Adenocarcinomas

Sholl, Lynette M.
Weremowicz, Stanislawa
Gray, Stacy W.
Wong, Kwok-Kin
Chirieac, Lucian R.
Lindeman, Neal I.
Hornick, Jason L.

March 2013

IntroductionALK gene rearrangements occur in approximately 5% of lung adenocarcinomas (ACAs), leadin...

Combined Use of ALK Immunohistochemistry and FISH for Optimal Detection of ALK-Rearranged Lung Adenocarcinomas

Sholl, Lynette Marie
Weremowicz, Stanislawa
Gray, Stacy
Wong, Kwok-Kin
Chirieac, Lucian Radu
Lindeman, Neal I.
Hornick, Jason L.

May 2017

INTRODUCTION ALK gene rearrangements occur in ~5% of lung adenocarcinomas (ACA), leading to ALK ove...

Correlation of the results between ALK IHC and FISH in all patients.

Kazuya Takamochi (440443)
Kengo Takeuchi (184615)
Takuo Hayashi (440444)
Shiaki Oh (440445)
Kenji Suzuki (157178)

August 2013

IHC, immunohistochemistry; FISH, fluorescent in situ hybridization.</p

Diagnostic algorithm that uses immunohistochemistry (IHC) as the primary test for identification anaplastic lymphoma kinase (ALK) positive in lung adenocarcinoma.

Jianya Zhou (542533)
Jing Zhao (21160)
Ke Sun (542534)
Bo Wang (86769)
Lijun Wang (176511)
Xi Chen (35903)
Jing Zheng (65946)
Qihan You (525773)
Xiaoling Wang (6503)
Wei Ding (690)
Jianying Zhou (506073)

March 2014

Dot lines correspond to that we also recommend initial ALK testing practice begins with IHC and f...

RNA-based analysis of ALK fusions in non-small cell lung cancer cases showing IHC/FISH discordance

Claudia Vollbrecht
Dido Lenze
Michael Hummel
Annika Lehmann
Markus Moebs
Nikolaj Frost
Philipp Jurmeister
Leonille Schweizer
Udo Kellner
Manfred Dietel
Maximilian von Laffert

November 2018

Abstract Background Rearrangements of the anaplastic lymphoma kinase (ALK) belong to the promising t...

Anaplastic lymphoma kinase (ALK) immunohistochemistry (IHC) staining using D5F3 antibody with Dako EnVision detection kit and fluorescence in situ hybridization(FISH) using Vysis LSI ALK probe in lung adenocarcinoma.

Jianya Zhou (542533)
Jing Zhao (21160)
Ke Sun (542534)
Bo Wang (86769)
Lijun Wang (176511)
Xi Chen (35903)
Jing Zheng (65946)
Qihan You (525773)
Xiaoling Wang (6503)
Wei Ding (690)
Jianying Zhou (506073)

March 2014

(A) IHC score 3+ for strong, granular cytoplasmic staining in most of tumor cells, at least more ...

French multicentric validation of ALK rearrangement diagnostic in 547 lung adenocarcinomas

Lantuejoul, Sylvie
Rouquette, Isabelle
Blons, Hélène
Le Stang, Nolwenn
Ilie, Marius
Begueret, Hugues
Grégoire, Valerie
Hofman, Paul
Gros, Audrey
Garcia, Stephane
Monhoven, Nathalie
Devouassoux-Shisheboran, Mojgan
Mansuet-Lupo, Audrey
Thivolet, Françoise
Antoine, Martine
Vignaud, Jean-Michel
Penault-Llorca, Frédérique
Galateau-Sallé, Françoise
Mcleer-Florin, Anne

June 2015

International audienceAnaplastic lymphoma kinase (ALK) gene rearrangements in lung adenocarcinoma re...

Performance of a RT-PCR Assay in Comparison to FISH and Immunohistochemistry for the Detection of ALK in Non-Small Cell Lung Cancer

David Hout

August 2017

Patients with lung cancers harboring an activating anaplastic lymphoma kinase (ALK) rearrangement re...

Accurate Identification of ALK Positive Lung Carcinoma Patients: Novel FDA-Cleared Automated Fluorescence In Situ Hybridization Scanning System and Ultrasensitive Immunohistochemistry

Conde, Esther
Suárez Gauthier, Ana
Benito, Amparo
Garrido, Pilar
García Campelo, Rosario
Biscuola, Michele
Paz-Ares, Luis
Hardisson, David
Castro, Javier de
Camacho, M. Carmen
Rodríguez Abreu, Delvys
Abdulkader, Ihab
Ramírez Ruz, J. (José)
Reguart, Noemí
Salido, Marta
Pijuan, Lara
Arriola, Edurne
Sanz, Julián
Folgueras, Victoria
Villanueva, Noemí
Gómez Román, Javier
Hidalgo, Manuel
López Ríos, Fernando

Background: Based on the excellent results of the clinical trials with ALK-inhibitors, the importanc...

Accurate identification of ALK positive lung carcinoma patients: novel FDA-cleared automated fluorescence in situ hybridization scanning system and ultrasensitive immunohistochemistry.

Esther Conde
Ana Suárez-Gauthier
Amparo Benito
Pilar Garrido
Rosario García-Campelo
Michele Biscuola
Luis Paz-Ares
David Hardisson
Javier de Castro
M Carmen Camacho
Delvys Rodriguez-Abreu
Ihab Abdulkader
Josep Ramirez
Noemí Reguart
Marta Salido
Lara Pijuán
Edurne Arriola
Julián Sanz
Victoria Folgueras
Noemí Villanueva
Javier Gómez-Román
Manuel Hidalgo
Fernando López-Ríos

BACKGROUND: Based on the excellent results of the clinical trials with ALK-inhibitors, the importanc...

Immunohistochemical screening for anaplastic lymphoma kinase (ALK) rearrangement in advanced non-small cell lung cancer patients

Park, Heae Surng
Lee, June Koo
Kim, Dong-Wan
Kulig, Kimary
Kim, Tae Min
Lee, Se-Hoon
Jeon, Yoon Kyung
Chung, Doo Hyun
Heo, Dae Seog

August 2012

Fluorescence in situ hybridization (FISH) is currently used to detect non-small cell lung cancer (NS...

Frequency of ALK rearrangement by FISH testing and its correlation with ALK-IHC in adenocarcinoma of primary lung origin

Moattar, Samar
Anwar, Namrah
Moatter, Tariq
Pervez, Shahid

June 2018

Anaplastic lymphoma kinase (ALK) gene can be oncogenic either by forming fusion with other genes, am...

Discordance between FISH, IHC, and NGS Analysis of ALK Status in Advanced Non–Small Cell Lung Cancer (NSCLC): a Brief Report of 7 Cases

Scattone A.
Catino A.
Schirosi L.
Caldarola L.
Tommasi S.
Lacalamita R.
Montagna E. S.
Galetta D.
Serio G.
Zito F. A.
Mangia A.

January 2019

BACKGROUND: Anaplastic lymphoma kinase (ALK) rearrangement represents a landmark in the targeted the...

Correlation of IHC and FISH for ALK Gene Rearrangement in Non-small Cell Lung Carcinoma: IHC Score Algorithm for FISH

Yi, Eunhee S.
Boland, Jennifer M.
Maleszewski, Joseph J.
Roden, Anja C.
Oliveira, Andre M.
Aubry, Marie-Christine
Erickson-Johnson, Michele R.
Caron, Bolette L.
Li, Yan
Tang, Hui
Stoddard, Shawn
Wampfler, Jason
Kulig, Kimary
Yang, Ping

March 2011

Introduction:Accurate, cost-effective methods for testing anaplastic lymphoma kinase gene rearrangem...

Three discrepant cases which had ALK IHC3+ and FISH “negative” results.

Jianya Zhou (542533)
Jing Zhao (21160)
Ke Sun (542534)
Bo Wang (86769)
Lijun Wang (176511)
Xi Chen (35903)
Jing Zheng (65946)
Qihan You (525773)
Xiaoling Wang (6503)
Wei Ding (690)
Jianying Zhou (506073)

March 2014

ALK, anaplastic lymphoma kinase; IHC, immunohistochemistry; FISH, fluorescence in situ hybridizat...

Combined Use of ALK Immunohistochemistry and FISH for Optimal Detection of ALK-Rearranged Lung Adenocarcinomas

Sholl, Lynette M.
Weremowicz, Stanislawa
Gray, Stacy W.
Wong, Kwok-Kin
Chirieac, Lucian R.
Lindeman, Neal I.
Hornick, Jason L.

March 2013

IntroductionALK gene rearrangements occur in approximately 5% of lung adenocarcinomas (ACAs), leadin...

Combined Use of ALK Immunohistochemistry and FISH for Optimal Detection of ALK-Rearranged Lung Adenocarcinomas

Sholl, Lynette Marie
Weremowicz, Stanislawa
Gray, Stacy
Wong, Kwok-Kin
Chirieac, Lucian Radu
Lindeman, Neal I.
Hornick, Jason L.

May 2017

INTRODUCTION ALK gene rearrangements occur in ~5% of lung adenocarcinomas (ACA), leading to ALK ove...

Correlation of the results between ALK IHC and FISH in all patients.

Kazuya Takamochi (440443)
Kengo Takeuchi (184615)
Takuo Hayashi (440444)
Shiaki Oh (440445)
Kenji Suzuki (157178)

August 2013

IHC, immunohistochemistry; FISH, fluorescent in situ hybridization.</p

Diagnostic algorithm that uses immunohistochemistry (IHC) as the primary test for identification anaplastic lymphoma kinase (ALK) positive in lung adenocarcinoma.

Jianya Zhou (542533)
Jing Zhao (21160)
Ke Sun (542534)
Bo Wang (86769)
Lijun Wang (176511)
Xi Chen (35903)
Jing Zheng (65946)
Qihan You (525773)
Xiaoling Wang (6503)
Wei Ding (690)
Jianying Zhou (506073)

March 2014

Dot lines correspond to that we also recommend initial ALK testing practice begins with IHC and f...

RNA-based analysis of ALK fusions in non-small cell lung cancer cases showing IHC/FISH discordance

Claudia Vollbrecht
Dido Lenze
Michael Hummel
Annika Lehmann
Markus Moebs
Nikolaj Frost
Philipp Jurmeister
Leonille Schweizer
Udo Kellner
Manfred Dietel
Maximilian von Laffert

November 2018

Abstract Background Rearrangements of the anaplastic lymphoma kinase (ALK) belong to the promising t...

Anaplastic lymphoma kinase (ALK) immunohistochemistry (IHC) staining using D5F3 antibody with Dako EnVision detection kit and fluorescence in situ hybridization(FISH) using Vysis LSI ALK probe in lung adenocarcinoma.

Jianya Zhou (542533)
Jing Zhao (21160)
Ke Sun (542534)
Bo Wang (86769)
Lijun Wang (176511)
Xi Chen (35903)
Jing Zheng (65946)
Qihan You (525773)
Xiaoling Wang (6503)
Wei Ding (690)
Jianying Zhou (506073)

March 2014

(A) IHC score 3+ for strong, granular cytoplasmic staining in most of tumor cells, at least more ...

French multicentric validation of ALK rearrangement diagnostic in 547 lung adenocarcinomas

Lantuejoul, Sylvie
Rouquette, Isabelle
Blons, Hélène
Le Stang, Nolwenn
Ilie, Marius
Begueret, Hugues
Grégoire, Valerie
Hofman, Paul
Gros, Audrey
Garcia, Stephane
Monhoven, Nathalie
Devouassoux-Shisheboran, Mojgan
Mansuet-Lupo, Audrey
Thivolet, Françoise
Antoine, Martine
Vignaud, Jean-Michel
Penault-Llorca, Frédérique
Galateau-Sallé, Françoise
Mcleer-Florin, Anne

June 2015

International audienceAnaplastic lymphoma kinase (ALK) gene rearrangements in lung adenocarcinoma re...

Performance of a RT-PCR Assay in Comparison to FISH and Immunohistochemistry for the Detection of ALK in Non-Small Cell Lung Cancer

David Hout

August 2017

Patients with lung cancers harboring an activating anaplastic lymphoma kinase (ALK) rearrangement re...

Accurate Identification of ALK Positive Lung Carcinoma Patients: Novel FDA-Cleared Automated Fluorescence In Situ Hybridization Scanning System and Ultrasensitive Immunohistochemistry

Conde, Esther
Suárez Gauthier, Ana
Benito, Amparo
Garrido, Pilar
García Campelo, Rosario
Biscuola, Michele
Paz-Ares, Luis
Hardisson, David
Castro, Javier de
Camacho, M. Carmen
Rodríguez Abreu, Delvys
Abdulkader, Ihab
Ramírez Ruz, J. (José)
Reguart, Noemí
Salido, Marta
Pijuan, Lara
Arriola, Edurne
Sanz, Julián
Folgueras, Victoria
Villanueva, Noemí
Gómez Román, Javier
Hidalgo, Manuel
López Ríos, Fernando

Background: Based on the excellent results of the clinical trials with ALK-inhibitors, the importanc...

Accurate identification of ALK positive lung carcinoma patients: novel FDA-cleared automated fluorescence in situ hybridization scanning system and ultrasensitive immunohistochemistry.

Esther Conde
Ana Suárez-Gauthier
Amparo Benito
Pilar Garrido
Rosario García-Campelo
Michele Biscuola
Luis Paz-Ares
David Hardisson
Javier de Castro
M Carmen Camacho
Delvys Rodriguez-Abreu
Ihab Abdulkader
Josep Ramirez
Noemí Reguart
Marta Salido
Lara Pijuán
Edurne Arriola
Julián Sanz
Victoria Folgueras
Noemí Villanueva
Javier Gómez-Román
Manuel Hidalgo
Fernando López-Ríos

BACKGROUND: Based on the excellent results of the clinical trials with ALK-inhibitors, the importanc...

Immunohistochemical screening for anaplastic lymphoma kinase (ALK) rearrangement in advanced non-small cell lung cancer patients

Park, Heae Surng
Lee, June Koo
Kim, Dong-Wan
Kulig, Kimary
Kim, Tae Min
Lee, Se-Hoon
Jeon, Yoon Kyung
Chung, Doo Hyun
Heo, Dae Seog

August 2012

Fluorescence in situ hybridization (FISH) is currently used to detect non-small cell lung cancer (NS...

Frequency of ALK rearrangement by FISH testing and its correlation with ALK-IHC in adenocarcinoma of primary lung origin

Moattar, Samar
Anwar, Namrah
Moatter, Tariq
Pervez, Shahid

June 2018

Anaplastic lymphoma kinase (ALK) gene can be oncogenic either by forming fusion with other genes, am...

Relationship between ALK IHC and FISH in the unselected 368 lung adenocarcinomas analysis.

Abstract

Extracted data

Relationship between ALK IHC and FISH in the unselected 368 lung adenocarcinomas analysis.

Abstract

Extracted data

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