Effect of the rs7560488 T>C polymorphism on DNMT3A1 promoter transcription activity.

<p>(A) Schematic representation of reporter plasmids containing the rs7560488 T or rs7560488 C allele, which was inserted upstream of the luciferase reporter gene in the pGL3 basic plasmid. (B) The two constructs were transiently transfected into the AGS and BGC-823 cells respectively. The luciferase activity of each construct was normalized against the internal control of Renilla luciferase. Columns mean from three independent experiments; bars, SD. *, P<0.01 compared with the construct counterpart.