a<p>Although not shown here, the model also included age at first insulin prescription (FIP), gender, time between screening and FIP, treatment intensity level and all other available oral or insulin categories as both cumulative exposure and time-dependent ever exposed terms (see Methods).</p>b<p>SHR, subhazard ratios, similar to hazard ratios from the classic Cox regression.</p>c<p>Significant result rounded up to <0.05 due to very low estimated SHR.</p
BACKGROUND: This study was aimed to assess the risk of breast cancer associated with exposure to ins...
Observational drug safety studies may be susceptible to confounding or protopathic bias. This bias m...
Observational drug safety studies may be susceptible to confounding or protopathic bias. This bias m...
<p>CI, confidence interval; HR, hazard ratio. Note: Unadjusted HR and 95% CI were obtained from a Co...
OBJECTIVEdTo add to the evidence on comparative long-term effects of insulin analog glargine versus ...
OBJECTIVE—In vitro evidence suggests insulin glargine promotes tumors; observational human studies a...
<p>Blue = insulin monotherapy, green = insulin plus metformin. Time zero refers to index date plus 1...
<p>Hazard ratios and their 95% CIs were obtained from Cox proportional hazards models adjusted for g...
<p>Notes: Final model specification: estimated cumulative insulin dose, therapy (±metformin), HbA1c,...
Aims: To test the hypothesis that cumulative exposure to insulin and long-acting insulin analogs mig...
Recent studies suggested that insulin glargine use could be associated with increased risk of cancer...
<p>For the overall model, there was evidence that the proportional hazards assumption was violated f...
OBJECTIVETo add to the evidence on comparative long-term effects of insulin analog glargine versus h...
textabstractAims/hypothesis Several publications suggest an association between certain types of ins...
Background: This study was aimed to assess the risk of breast cancer associated with exposure to ins...
BACKGROUND: This study was aimed to assess the risk of breast cancer associated with exposure to ins...
Observational drug safety studies may be susceptible to confounding or protopathic bias. This bias m...
Observational drug safety studies may be susceptible to confounding or protopathic bias. This bias m...
<p>CI, confidence interval; HR, hazard ratio. Note: Unadjusted HR and 95% CI were obtained from a Co...
OBJECTIVEdTo add to the evidence on comparative long-term effects of insulin analog glargine versus ...
OBJECTIVE—In vitro evidence suggests insulin glargine promotes tumors; observational human studies a...
<p>Blue = insulin monotherapy, green = insulin plus metformin. Time zero refers to index date plus 1...
<p>Hazard ratios and their 95% CIs were obtained from Cox proportional hazards models adjusted for g...
<p>Notes: Final model specification: estimated cumulative insulin dose, therapy (±metformin), HbA1c,...
Aims: To test the hypothesis that cumulative exposure to insulin and long-acting insulin analogs mig...
Recent studies suggested that insulin glargine use could be associated with increased risk of cancer...
<p>For the overall model, there was evidence that the proportional hazards assumption was violated f...
OBJECTIVETo add to the evidence on comparative long-term effects of insulin analog glargine versus h...
textabstractAims/hypothesis Several publications suggest an association between certain types of ins...
Background: This study was aimed to assess the risk of breast cancer associated with exposure to ins...
BACKGROUND: This study was aimed to assess the risk of breast cancer associated with exposure to ins...
Observational drug safety studies may be susceptible to confounding or protopathic bias. This bias m...
Observational drug safety studies may be susceptible to confounding or protopathic bias. This bias m...