Chronically injured <i>Pdgfrα^WT/nGFP</i> mice have less collagen deposition than C57BL/6 mice.

<p>Mice were injected with olive oil or CCl₄ twice weekly for 4 weeks and collagen was detected in liver tissue by picrosirius red staining. A) Liver from a mouse injected with oil shows little collagen deposition. B) C57BL/6 mice develop fibrosis (arrow) after 4 weeks of CCl₄ injections. C) <i>Pdgfrα^WT/nGFP</i> mice develop less fibrosis (arrow) than C57BL/6 mice after 4 weeks of CCl₄ injections. D) Quantification of picrosirius red positive area. Values are represented as means with SEM, and were analyzed by Mann-Whitney non-parametric U test * = p<0.05, n = 3–6 mice per time point. Scale bars are 100 μm.