Rat body weight gained during treatment (vehicle, olanzapine, olanzapine + berberine, olanzapine + metformin) (A).

<p>* denotes significant difference between olanzapine and control group at P<0.05; # denotes significant difference between olanzapine + berberine and olanzapine group at P<0.05; † denotes significant difference between olanzapine + metformin and olanzapine group at P<0.05. (B) Average food intake (g/rat/day) for each treatment group. (C) Rat white fat, brown fat, and liver weight percentage normalized to body weight in eacg treatment group. * denotes significant difference at P<0.05.